Home » Chromosomal Translocations And Oncogenic Transcription Factors by Frank J. Rauscher III
Chromosomal Translocations And Oncogenic Transcription Factors Frank J. Rauscher III

Chromosomal Translocations And Oncogenic Transcription Factors

Frank J. Rauscher III

Published April 11th 1997
ISBN : 9783540614029
Hardcover
166 pages
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 About the Book 

Regulation of gene expression at the level of transcription is one of the major determinants of proper cellular proliferation and differentiation. The key players in these processes are sequence-specific DNA binding transcription factor proteinsMoreRegulation of gene expression at the level of transcription is one of the major determinants of proper cellular proliferation and differentiation. The key players in these processes are sequence-specific DNA binding transcription factor proteins which coordinate programs of gene expression in the nucleus. The articles in this volume document the myriad of genetic and biochemical alterations sustained by human proto-oncogenic transcription factors which result in diverse neoplastic processes. This volume gives insights into how normal programs of gene expression can be subverted by the action of single transcription factors resulting in a specific tumor type. The book provides inspiration for exploiting these tumor-specific alterations as diagnostic, prognostic tools, or as selective therapeutic targets.